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Utilization of 3D ultrasonography for nuchal translucency measurment
Širůčková, Anna ; Harabiš, Vratislav (referee) ; Kolář, Radim (advisor)
This thesis is review of the newest methods of diagnose congenital defects of fetus in first trimester mainly Down´s syndrome. Nuchal translucency is primary marker for assessment the risk of aneuploidy. The aim of this project is to clarify the most modern techniques, three dimensional ultrasound, using for measuring of nuchal translucency. Fetal Medicine Foundation set straight guidelines for measuring, practice and audits, which are recommended. In this thesis, the focus is also on possible ways of audit by quantitative and qualitative evaluation. In the last part, I designed the study for evaluation of presented techniques. The aim is to qualify the benefits of tool Sono NT and Volume NT.
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Assessment of the uncertainty of the ultrasound nuchal translucency measurement
Matejková, Magdaléna ; Pavlík,, Tomáš (referee) ; Jarkovský,, Jiří (advisor)
The issue of congenital malformations in the fetus is important part of fetal medicine. This project is comparing the measurement uncertainty of congenital malformations in the fetus markers and it is focused on screening markers in first and second trimester of pregnancy. The recommendations of Fetal Medicine Foundation (FMF) are decisive in this project. The issues of determination measurement uncertainty in biochemical laboratory and measurement uncertainty of ultrasound markers are also mentioned. These both issues are compared and methodology of measurement uncertainty determination of nuchal translucency ultrasound marker is designed. The methodic is based on biochemical determination of measurement uncertainty. The methodic is then realized on the data set from six medical doctors and is statistically evaluated.
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Automated Measurement of Ultrasound Markers of Congenital Fetal Abnormalities
Szpyrc, Bogdan ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This work deals with displaying and measuring ultrasonic markers of congenital defects of the fetus in first trimester of pregnancy. Background research of ultrasonic markers was based on the studies of prof. Kypros Nicolaides (Great Britain), the president of the Fetal Medicine Foundation. This work contains a brief description of diagnosing of congenital defects during all three trimesters, and lists in detail defects that can be diagnosed properly during first trimester, as well as methods of calculating the risk of chromosomal abnormalities. In the next parts of this work, there are descriptions of methods used to improve results while measuring nuchal translucence (NT) strongest marker of Down syndrome in first trimester. The imaging capabilities of ultrasound devices were tested. Using scanned images, the influence of different display parameters on the resolution could be determined. Furthermore, using recommendations of the FMF, algorithms for adjusting correct slice of fetus and automatic measurement NT were designed and tested. A program application was designed that enabled testing of those algorithms on real images and calculating risks of chromosomal abnormalities from CRL and NT value. Designed algorithms were tested on real images. The program application, in witch the algorithms for measuring NT (NT detection algorithms) are included, was created.
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Optimized methodology of caliper positioning for ultrasound measurement of nuchal translucence
Kolářová, Dana ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This thesis focuses on the research of methods for first trimester screening of congenital defects of the fetus. Ultrasound markers of aneuploidy, the algorithm of the first trimester screening and brief description of chromosomal aberrations diagnosable in the first trimester of pregnancy are described in the literature search. Nuchal translucency is the most important marker of aneuploidy in the first trimester and the work also deals with the measurement methodology currently used, which was created by the Fetal Medicine Foundation (FMF). The aim is to describe the limitations of the methodology and explain inaccuracies that arise due to FMF recommendations. The biggest drawback of the methodology is the influence of parameters set on ultrasound machines before and during the actual measurement, therefore it is necessary to come with new methodology not affected by them. The new methodology is based on the knowledge of the parameter influence and is independent of parameter settings of ultrasound machines. The final part of the thesis includes a study comparing the standard derivation of measurement results in both methods.
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Utilization of 3D ultrasonography for nuchal translucency measurment
Širůčková, Anna ; Harabiš, Vratislav (referee) ; Kolář, Radim (advisor)
This thesis is review of the newest methods of diagnose congenital defects of fetus in first trimester mainly Down´s syndrome. Nuchal translucency is primary marker for assessment the risk of aneuploidy. The aim of this project is to clarify the most modern techniques, three dimensional ultrasound, using for measuring of nuchal translucency. Fetal Medicine Foundation set straight guidelines for measuring, practice and audits, which are recommended. In this thesis, the focus is also on possible ways of audit by quantitative and qualitative evaluation. In the last part, I designed the study for evaluation of presented techniques. The aim is to qualify the benefits of tool Sono NT and Volume NT.
|
|
|
Optimized methodology of caliper positioning for ultrasound measurement of nuchal translucence
Kolářová, Dana ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This thesis focuses on the research of methods for first trimester screening of congenital defects of the fetus. Ultrasound markers of aneuploidy, the algorithm of the first trimester screening and brief description of chromosomal aberrations diagnosable in the first trimester of pregnancy are described in the literature search. Nuchal translucency is the most important marker of aneuploidy in the first trimester and the work also deals with the measurement methodology currently used, which was created by the Fetal Medicine Foundation (FMF). The aim is to describe the limitations of the methodology and explain inaccuracies that arise due to FMF recommendations. The biggest drawback of the methodology is the influence of parameters set on ultrasound machines before and during the actual measurement, therefore it is necessary to come with new methodology not affected by them. The new methodology is based on the knowledge of the parameter influence and is independent of parameter settings of ultrasound machines. The final part of the thesis includes a study comparing the standard derivation of measurement results in both methods.
|
|
|
Assessment of the uncertainty of the ultrasound nuchal translucency measurement
Matejková, Magdaléna ; Pavlík,, Tomáš (referee) ; Jarkovský,, Jiří (advisor)
The issue of congenital malformations in the fetus is important part of fetal medicine. This project is comparing the measurement uncertainty of congenital malformations in the fetus markers and it is focused on screening markers in first and second trimester of pregnancy. The recommendations of Fetal Medicine Foundation (FMF) are decisive in this project. The issues of determination measurement uncertainty in biochemical laboratory and measurement uncertainty of ultrasound markers are also mentioned. These both issues are compared and methodology of measurement uncertainty determination of nuchal translucency ultrasound marker is designed. The methodic is based on biochemical determination of measurement uncertainty. The methodic is then realized on the data set from six medical doctors and is statistically evaluated.
|
|
|
Automated Measurement of Ultrasound Markers of Congenital Fetal Abnormalities
Szpyrc, Bogdan ; Kolář, Radim (referee) ; Provazník, Ivo (advisor)
This work deals with displaying and measuring ultrasonic markers of congenital defects of the fetus in first trimester of pregnancy. Background research of ultrasonic markers was based on the studies of prof. Kypros Nicolaides (Great Britain), the president of the Fetal Medicine Foundation. This work contains a brief description of diagnosing of congenital defects during all three trimesters, and lists in detail defects that can be diagnosed properly during first trimester, as well as methods of calculating the risk of chromosomal abnormalities. In the next parts of this work, there are descriptions of methods used to improve results while measuring nuchal translucence (NT) strongest marker of Down syndrome in first trimester. The imaging capabilities of ultrasound devices were tested. Using scanned images, the influence of different display parameters on the resolution could be determined. Furthermore, using recommendations of the FMF, algorithms for adjusting correct slice of fetus and automatic measurement NT were designed and tested. A program application was designed that enabled testing of those algorithms on real images and calculating risks of chromosomal abnormalities from CRL and NT value. Designed algorithms were tested on real images. The program application, in witch the algorithms for measuring NT (NT detection algorithms) are included, was created.
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